Colon Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Colon Cancer, including details on causes, treatment, symptoms.

Prolactinoma as the first manifestation of Gardner's syndrome.

Goodin GS, McCarville MB, Thibodeau SN, Skapek SX, Khoury JD, Spunt SL

Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Familial adenomatous polyposis (FAP) is an inherited condition causing numerous adenomatous colorectal polyps and a markedly elevated risk of colon cancer. FAP may be associated with various extracolonic manifestations such as desmoid fibromatosis and osteomas (termed Gardner's syndrome) and brain tumors, usually medulloblastoma or glioma [termed Brain Tumor Polyposis (BTP) syndrome type 2]. We describe a pediatric patient who initially presented with prolactinoma and later was found to have Gardner's syndrome. A germline mutation of the APC (adenomatous polyposis coli) gene was identified. Our case illustrates the association between prolactinoma and FAP, which may represent a rare subtype of Gardner's and BTP syndromes.

Published 12 December 2007 in Pediatr Blood Cancer, 50(2): 409-12.
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