Colon Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Colon Cancer, including details on causes, treatment, symptoms.

Ocular manifestations of familial adenomatous polyposis (Gardner syndrome).

Traboulsi EI

Department of Pediatric Ophthalmology and Strabismus and the Center for Genetic Eye Disease, Cole Eye Institute, Cleveland Clinic Foundation (i32), 9500 Euclid Avenue, Cleveland, OH 44195, USA. traboue@ccf.org

Familial adenomatous polyposis (FAP) is a colon cancer predisposition syndrome in which hundreds to thousands of precancerous colonic polyp become evident at a mean age of 16 years (range, 7-36 years). By age 35 years, 95% of patients have polyps. Gardner syndrome is the eponym given to a subgroup of FAP with extracolonic manifestations, such as pigmented ocular fundus lesions that resemble congenital hypertrophy of the retinal pigment epithelium, among others.

Published 14 March 2005 in Ophthalmol Clin North Am, 18(1): 163-6, x.
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