Colon Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Colon Cancer, including details on causes, treatment, symptoms.

Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles.

Qi L, Xu Z, Jiang X, Li Y, Wang M

Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Animal Science college, Zhejiang University, Hangzhou 310029, PR China. lfqi@zju.edu.cn

Chitosan nanoparticles and copper(II)-loaded chitosan nanoparticles were prepared based on the ionic gelation of chitosan with tripolyphosphate anions and copper ion sorption. In this study, the cytotoxic activities of the chitosan nanoparticles and copper(II)-loaded chitosan nanoparticles was investigated and a relationship between physiochemical properties and activity is suggested. The chitosan nanoparticles and copper(II)-loaded chitosan nanoparticles elicited dose-dependent inhibitory effects on the proliferation of tumor cell lines.

Published 16 February 2005 in Bioorg Med Chem Lett, 15(5): 1397-9.
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